Protein design guides

Guides on de novo protein and antibody design, inverse folding, and developability screening.

Protein ribbon beside separate license documents labeled Code and Weights.

Structures ·

AlphaFold license and commercial use

AlphaFold 2 and the AlphaFold Database allow commercial use, while the AlphaFold 3 weights and AlphaFold Server do not. See what each license allows and which models, including Boltz-2, Chai-1, RFdiffusion and ESM, companies can use.

Ink illustration of an antibody and a magnified binding domain with an engineered loop.

Antibodies ·

What is antibody engineering?

Antibody engineering changes an antibody's sequence or structure to improve binding, reduce immunogenicity, tune effector function or create new formats. Learn the core techniques and computational workflows.

Two protein chains with low-PAE residue pairs highlighted at their interface and faint flexible tails

Structures ·

ipSAE explained

ipSAE is an interface confidence score for AlphaFold2, AlphaFold3 and Boltz that ignores disordered tails. Learn how it is calculated, why it beats ipTM and what 0.6 to 0.8 mean.

Ink illustration of a designed antibody domain approaching a target protein.

Antibodies ·

What is Chai-2? De novo antibody design explained

Understand what Chai-2 designs, what its experimental hit rates mean, how access works, and which open tools address related antibody and protein binder tasks.