ProteinIQ
Sign inStart for free
ProteinIQ
Genetics

How much DNA do cousins share?

First cousins share 12.5% of their autosomal DNA by descent on average. The expected share falls to 3.125% for second cousins and 0.781% for third cousins.

July 27, 2026·Matic Broz, PhD
Two DNA helices with corresponding segments illustrating shared inherited DNA.

First cousins share 12.5% of their autosomal DNA by descent on average. Second cousins average 3.125%, while third cousins average 0.781%.

These are expected values, not fixed results. Recombination shuffles DNA in every generation, so two confirmed cousins can share more or less than the average.

How much DNA do cousins share?

The expected autosomal DNA share is 12.5% for first cousins, 6.25% for first cousins once removed, 3.125% for second cousins, and 0.781% for third cousins.[1]

Each step down the family tree halves the expected amount inherited from the shared ancestors. First cousins descend from the same grandparents. Second cousins share great-grandparents, and third cousins share great-great-grandparents.

The expected percentage of autosomal DNA shared by first cousins, first cousins once removed, second cousins, second cousins once removed, and third cousins

Consumer tests often report shared DNA in centimorgans (cM), a measure based on the probability of recombination rather than physical DNA length. The Shared cM Project collected nearly 60,000 submissions for known relationships and retained 55,418 records after curation and outlier removal.[2]

RelationshipExpected shareObserved averageTrimmed observed range
First cousin12.5%866 cM396-1,397 cM
First cousin once removed6.25%433 cM102-980 cM
Second cousin3.125%229 cM41-592 cM
Second cousin once removed1.563%122 cM14-353 cM
Third cousin0.781%73 cM0-234 cM

The observed values come from the Shared cM Project. It removed 0.5% of submissions at each end of every relationship distribution; for relationships as distant as third cousins, it set the minimum to 0 cM and calculated the average only among pairs with detectable shared DNA.[2]

The expected percentages describe DNA inherited from recent common ancestors. They differ from the roughly 50% shared by full siblings and from ordinary sequence similarity between any two people.

How much DNA do first cousins share?

First cousins share 12.5% of their autosomal DNA by descent on average, equivalent to about 850 cM under the standard inheritance model.[1][2]

The Shared cM Project found an observed average of 866 cM across 3,337 first-cousin pairs, with a trimmed range of 396 to 1,397 cM. 23andMe reports a broader expected range of 8% to 22% for the category that includes first cousins and other relationships at the same genealogical distance.[2][3]

First cousins share a pair of grandparents. Along the path from one cousin to the other, each grandparent's DNA passes through four parent-to-child transmissions. Each shared grandparent therefore contributes an expected (1/2)4, or 1/16; the two grandparents together contribute 1/8, or 12.5%.

The actual result varies because eggs and sperm receive recombinant mixtures of chromosome copies rather than exact quarters from each grandparent.[4] A result above or below 12.5% can therefore fit a genuine first-cousin relationship.

How much DNA do second cousins share?

Second cousins share 3.125% of their autosomal DNA by descent on average, equivalent to about 213 cM under the standard inheritance model.[1][2]

The Shared cM Project observed an average of 229 cM across 4,172 second-cousin pairs, with a trimmed range of 41 to 592 cM. 23andMe reports an average of 3.4% and an expected range of 1.1% to 6.3%.[2][3]

Second cousins share a pair of great-grandparents. Two more parent-to-child transmissions separate them than first cousins, so their expected shared fraction is one-quarter as large: 3.125% instead of 12.5%.

The ranges for different relationships overlap. A shared total of 400 cM, for example, can fit a low-sharing first cousin once removed or a high-sharing second cousin. A centimorgan total narrows the possibilities, but ages, family trees, shared matches, and the number and location of segments help identify the relationship.[2][3]

Can cousins share no DNA?

First and second cousins are expected to share at least one inherited autosomal segment, but more distant cousins can share no detectable DNA from their common ancestors.[1]

A 2026 study simulated 100,000 pairs for each cousin relationship using sex-specific genetic maps and crossover interference. All simulated first and second cousins shared at least one identical-by-descent segment. Among third cousins, 98.5% shared at least one segment, leaving about 1.5% with none.[1]

Detection also depends on the testing company's minimum segment length and matching algorithm. Short segments are harder to distinguish from noise, so two genealogical cousins can be related even when a consumer test shows no match.

The percentages here do not mean that first cousins have only 12.5% of their DNA letters in common. A sequence aligner such as MUMmer4 compares base-level similarity and differences, while cousin matching looks for long chromosome segments inherited from the same recent ancestors. Those are different measurements.

Sources4 references
  1. The rate of identical-by-descent segment sharing between close and distant relatives

    Human Genetics and Genomics Advances · 2026

  2. The Shared cM Project, Version 4.0

    The Genetic Genealogist · 2020

  3. Average Percent DNA Shared Between Relatives

    23andMe Customer Care · July 27, 2026

  4. How Are Physical Features and Health Conditions Inherited?

    National Institute of General Medical Sciences · 2024

About the author

Matic Broz, PhD

Matic Broz, PhD

Founder and computational chemist, ProteinIQ

Dr. Matic Broz is the founder of ProteinIQ and a computational chemist. He completed a PhD focused on protein structure, molecular dynamics, and neural networks, and writes about structural biology and scientific software.

LinkedInGoogle ScholarORCID
Published
July 27, 2026
Last updated
July 27, 2026

Related guides

Browse all guides
Two DNA segments with matching regions illustrating shared inheritance between siblings.

Genetics · July 27, 2026

How much DNA do siblings share?

Full siblings share about 50% of their autosomal DNA by descent on average. Identical twins share virtually 100%, while half-siblings average 25%.

Cutaway mitochondrion with an enlarged circular mitochondrial DNA molecule.

Genetics · September 19, 2026

How many genes are in mitochondrial DNA?

Human mitochondrial DNA has 37 canonical genes. Compare the standard count with evidence for additional small proteins and mtDNA copy numbers across tissues.

Illustration comparing a human, chimpanzee, mouse, dog, chicken, and zebrafish.

Genetics · September 19, 2026

How much DNA do humans share with other animals?

Human and chimpanzee DNA is about 98.8% identical across directly aligned bases. See how animal comparisons change when studies count DNA letters, proteins, or shared genes.

ProteinIQ

© 2026 ProteinIQ

Products

  • Bioinformatics tools
  • Workflows
  • Batches
  • PDB viewer
  • API

Solutions

  • Small molecule
  • RNA discovery
  • Antibody engineering
  • Peptide discovery
  • Enzyme engineering
  • Protein engineering
  • Virtual screening
  • Molecular docking
  • Protein structure prediction
  • RNA structure prediction
  • Protein structure alignment
  • Protein design
  • Sequence alignment
  • Phylogenetic analysis
  • Molecular dynamics simulation
  • For academia
  • For enterprise

Resources

  • Documentation
  • Blog
  • Guides
  • Datasets
  • Changelog
  • Sitemap

Company

  • About
  • Contact
  • Enterprise
  • Pricing
  • Security
  • Trust center
  • Author
  • Legal
  • Terms
  • Privacy policy

Connect

  • LinkedIn
  • X
  • Discord
  • Pricing