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Folding

Structure prediction

AlphaFold2 Boltz-2 Chai-1 ESMfold OpenFold-3 Protenix RosettaFold3

Inverse folding

ProteinMPNN SolubleMPNN LigandMPNN ESM-IF1

De novo

RFdiffusion RFdiffusion 2 RFdiffusion 3 BoltzGen PocketFlow

App

Rfdiffusion 2

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RFdiffusion 2Beta

AI-powered atom-level enzyme active site scaffolding for precise protein design

protein-design enzyme-design diffusion-model ai-powered protein