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Guides
Antibodies ·
How to use BioPhi online
Learn how to run BioPhi online, choose between Sapiens and OASis modes, prepare VH and VL inputs, interpret humanness scores and mutations, troubleshoot warnings, and validate humanized antibodies.
Design ·
How to use BoltzGen online
Learn how to run BoltzGen online, choose a binder protocol and target site, configure a design campaign, interpret ranked structures and metrics, and plan experimental validation.
Antibodies ·
How to use AntiFold online
Learn how to use AntiFold online, prepare an IMGT-numbered antibody structure, choose chains and design regions, sample sequences, interpret likelihood scores, and validate candidates.
Antibodies ·
How to use CoSiNE online
Learn how to run CoSiNE online for paired-antibody variant effect prediction, prepare a DMS CSV, choose heavy, light, or combined scoring, apply neutral SHM correction, interpret result files, and validate candidate rankings.
Antibodies ·
How to use DeepViscosity online
Learn how to run DeepViscosity online from paired antibody Fv sequences, prepare the required CSV, interpret Prob_Mean, Prob_Std, classes, and DeepSP descriptors, and plan experimental validation.
Antibodies ·
How to use DiffAb online
Learn how to run DiffAb online, prepare an antibody or antibody–antigen PDB, choose among five CDR design modes, interpret native output files, and validate unranked candidates.
Antibodies ·
How to use TAP2 online
Learn how to run TAP2 online, prepare antibody VH and VL sequences, interpret PSH, PPC, PNC, SFvCSP, and CDR-length flags, and understand how ProteinIQ independently reconstructed and validated the published method.
Antibodies ·
What is antibody engineering? Techniques, formats, and computational workflows
Antibody engineering is the deliberate modification of antibody sequences and structures to improve binding, reduce immunogenicity, tune effector function, or create new formats. Learn the core techniques and the computational workflows behind modern antibody design.
Antibodies ·
What is Chai-2? De novo antibody design explained
Chai-2 is an AI model for de novo antibody and protein binder design. Learn how it works, its performance benchmarks, access options, and alternatives for computational binder design.