
Input
Use SMILES/SDF/MOL for small-molecule docking. native PocketXMol treats PDB ligand files and pepseq_<sequence> text as peptide docking inputs.

PocketFlow is a structure-based molecular generative model that designs novel drug-like molecules within protein binding pockets. It uses autoregressive flow modeling with chemical knowledge to generate 100% chemically valid, highly drug-like compounds.

BoltzGen is a state-of-the-art AI model for designing protein and peptide binders against any biomolecular target. Using generative diffusion models, it creates novel binders (proteins, peptides, nanobodies) with nanomolar-level binding affinity.

GenMol is a generative AI model from NVIDIA that creates novel drug-like molecules using masked discrete diffusion. It generates molecules in SAFE representation format and supports de novo generation, linker design, motif extension, and scaffold decoration.

Design linear peptide binders for target proteins using a target sequence-conditioned masked language model. PepMLM generates peptide sequences optimized to bind specific protein targets based on ESM-2 protein language modeling.

EvoDiff is a diffusion-based protein sequence generation framework from Microsoft Research. ProteinIQ currently wraps the EvoDiff-Seq OA_DM_38M model for unconditional protein generation, motif scaffolding, and user-sequence inpainting.

All-atom generative AI for designing protein binders. Specify target binding sites and generate diverse binding proteins with fine-grained control over interaction parameters.

Reasoning-guided antibody CDR co-design for antibody-antigen complexes. Proteo-R1 identifies residue-level functional decisions and uses conditional diffusion to generate ranked designed structures with confidence metrics.

RFdiffusion is a state-of-the-art protein structure generation tool that uses diffusion models to design proteins de novo, create binders, scaffold motifs, and generate symmetric oligomers with atomic precision.

RFdiffusion2 is an atom-level enzyme active site scaffolding tool that generates protein scaffolds around your input motif. REQUIRES an input PDB structure containing the active site residues to scaffold. For ligand-aware design, ligands must be embedded in the input PDB as HETATM records.

ProGen2 is Salesforce Research's protein language model suite for prompt-based de novo protein sequence generation. It samples novel amino acid sequences from a plain-text context string using top-p sampling and temperature control.