Predict intrinsically disordered regions and per-residue disorder probabilities from protein sequences. Learn more
Input
Output
Configure inputs to begin
Set options on the left, then click “Submit job”.
DR-BERT webserver overview
DR-BERT predicts intrinsic protein disorder from amino acid sequences. ProteinIQ runs DR-BERT version 1.1.0 and returns continuous disorder scores from 0 to 1 for each scored residue, together with the native score file, a CSV table, a score profile, the prepared input, and a run log.
The scoring program evaluates the first 1022 residues of each submitted sequence. ProteinIQ does not add a disorder classification threshold to the continuous source scores.
Pricing
Each job costs 10 credits under the current limit of five sequences per job. Sequence count, sequence length, and the optional job name do not change this charge. The exact quote is shown before submission.
Inputs
| Input | Accepted values | Limits and behavior |
|---|---|---|
| Protein sequences | Raw one-letter amino acid sequence or FASTA | Submit 1 to 5 non-empty sequences in one input. Raw input is converted to uppercase and has whitespace removed. Complete FASTA headers are retained. |
| File upload | .fasta, .fa, or .txt | Maximum file size is 10 MiB. Each FASTA record must contain sequence data. |
| RCSB fetch | PDB ID | Protein sequences can be fetched from RCSB and submitted as FASTA. |
Sequences longer than 1022 residues are accepted, but only the first 1022 residues receive scores. The returned prepared FASTA and native pickle retain the complete submitted sequence.
Settings
| Parameter | Type | Default | Description |
|---|---|---|---|
| Job name | string | optional | Adds a user-defined name to the job. It does not affect scoring or credit cost. |
DR-BERT has no user-adjustable model or threshold settings.
Outputs
The Scores view contains one row per safely mapped residue.
| Field | Description |
|---|---|
sequence_id | FASTA header or submitted sequence label. Very long identifiers may be shortened in the table and CSV; the native pickle retains the complete identifier. |
position | One-based residue position within the sequence. |
residue | One-letter amino acid at that position. |
disorder_score | Continuous DR-BERT disorder score from 0 to 1. |
The Files view includes every returned artifact.
| File | Format | Description |
|---|---|---|
dr_bert_scores.pkl | Pickle | Native DR-BERT DataFrame with ID, sequence, and score columns. Each score value is a NumPy float32 array. |
dr_bert_residue_scores.csv | CSV | Portable per-residue table derived from the native pickle without rounding scores. |
dr_bert_score_profile.svg | SVG | Score profile by sequence position for every submitted sequence. |
dr_bert_input.fasta | FASTA | Exact FASTA passed to the DR-BERT scoring program. |
run.log | Log | Source and model revisions, runtime versions, input and scored residue counts, truncation count, mapping warnings, and returned artifact list. |
If DR-BERT returns a score count that cannot be mapped reliably to a submitted sequence, ProteinIQ preserves the native pickle and score profile but omits that sequence from the derived table and CSV. The result includes a warning instead of assigning scores to the wrong residues.
Understanding results
Higher disorder_score values indicate stronger model support for intrinsic disorder. The score remains a continuous model output rather than a binary classification. Use the profile alongside experimental evidence and other predictors when selecting construct boundaries or interpreting functional regions.
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