# Guides

Educational walkthroughs for computational biology workflows.

## #

- [15 most expensive drugs in the world](https://proteiniq.io/guides/most-expensive-drugs)/guides/most-expensive-drugs
- [58 E. coli statistics [2026]](https://proteiniq.io/guides/e-coli-statistics)/guides/e-coli-statistics

## A

- [AI drug discovery statistics [2026]](https://proteiniq.io/guides/ai-drug-discovery-statistics)/guides/ai-drug-discovery-statistics
- [AlphaFold database statistics [2026]](https://proteiniq.io/guides/alphafold-statistics)/guides/alphafold-statistics
- [AlphaFold license and commercial use](https://proteiniq.io/guides/alphafold-license-commercial-use)/guides/alphafold-license-commercial-use
- [Antibody variable regions: VH, VL, CDRs and frameworks](https://proteiniq.io/guides/antibody-variable-regions)/guides/antibody-variable-regions

## C

- [ChemDraw on Mac, Linux and Chromebook: your options](https://proteiniq.io/guides/chemdraw-for-mac)/guides/chemdraw-for-mac
- [ChemDraw price and licenses explained](https://proteiniq.io/guides/chemdraw-price)/guides/chemdraw-price
- [Chemical file formats compared: MOL, SDF, MOL2, CDX, SMILES and InChI](https://proteiniq.io/guides/chemical-file-formats)/guides/chemical-file-formats
- [ChemSketch Freeware is gone: what to use instead](https://proteiniq.io/guides/chemsketch-alternatives)/guides/chemsketch-alternatives
- [Codon optimization: what it changes and when it helps](https://proteiniq.io/guides/codon-optimization)/guides/codon-optimization

## D

- [Disulfide bonds in proteins: how they form and what they do](https://proteiniq.io/guides/disulfide-bonds)/guides/disulfide-bonds
- [DockQ score explained](https://proteiniq.io/guides/dockq)/guides/dockq
- [Drug discovery statistics [2026]](https://proteiniq.io/guides/drug-discovery-statistics)/guides/drug-discovery-statistics
- [Drug discovery trends in 2026](https://proteiniq.io/guides/drug-discovery-trends)/guides/drug-discovery-trends

## F

- [Fab and Fc regions of an antibody: structure and function](https://proteiniq.io/guides/fab-and-fc-regions-of-an-antibody)/guides/fab-and-fc-regions-of-an-antibody
- [From a drawn molecule to a docking result](https://proteiniq.io/guides/drawing-to-docking)/guides/drawing-to-docking

## G

- [GNINA CNN score vs CNN affinity: what each number means](https://proteiniq.io/guides/gnina-cnn-score)/guides/gnina-cnn-score
- [Guides](https://proteiniq.io/guides)/guides

## H

- [How accurate is DNA sequencing?](https://proteiniq.io/guides/dna-sequencing-accuracy)/guides/dna-sequencing-accuracy
- [How big is the human genome?](https://proteiniq.io/guides/human-genome-size)/guides/human-genome-size
- [How big is the human proteome?](https://proteiniq.io/guides/human-proteome-size)/guides/human-proteome-size
- [How long do clinical trials take?](https://proteiniq.io/guides/how-long-do-clinical-trials-take)/guides/how-long-do-clinical-trials-take
- [How long do proteins last in the body?](https://proteiniq.io/guides/how-long-do-proteins-last-in-the-body)/guides/how-long-do-proteins-last-in-the-body
- [How long does a drug patent last?](https://proteiniq.io/guides/how-long-does-a-drug-patent-last)/guides/how-long-does-a-drug-patent-last
- [How long does a western blot take?](https://proteiniq.io/guides/how-long-does-a-western-blot-take)/guides/how-long-does-a-western-blot-take
- [How long does DNA last?](https://proteiniq.io/guides/how-long-does-dna-last)/guides/how-long-does-dna-last
- [How long does DNA replication take?](https://proteiniq.io/guides/how-long-does-dna-replication-take)/guides/how-long-does-dna-replication-take
- [How long does it take to develop a vaccine?](https://proteiniq.io/guides/how-long-does-it-take-to-develop-a-vaccine)/guides/how-long-does-it-take-to-develop-a-vaccine
- [How long does it take to sequence a human genome?](https://proteiniq.io/guides/human-genome-sequencing-time)/guides/human-genome-sequencing-time
- [How long does mRNA last in a cell?](https://proteiniq.io/guides/how-long-does-mrna-last-in-a-cell)/guides/how-long-does-mrna-last-in-a-cell
- [How long does PCR take?](https://proteiniq.io/guides/how-long-does-pcr-take)/guides/how-long-does-pcr-take
- [How long is human DNA?](https://proteiniq.io/guides/how-long-is-dna)/guides/how-long-is-dna
- [How many amino acids are in a complete protein?](https://proteiniq.io/guides/how-many-amino-acids-are-in-a-complete-protein)/guides/how-many-amino-acids-are-in-a-complete-protein
- [How many amino acids are in hemoglobin?](https://proteiniq.io/guides/how-many-amino-acids-are-in-hemoglobin)/guides/how-many-amino-acids-are-in-hemoglobin
- [How many amino acids are in insulin?](https://proteiniq.io/guides/how-many-amino-acids-are-in-insulin)/guides/how-many-amino-acids-are-in-insulin
- [How many amino acids are there?](https://proteiniq.io/guides/how-many-amino-acids-are-there)/guides/how-many-amino-acids-are-there
- [How many antibiotics are there?](https://proteiniq.io/guides/how-many-antibiotics-are-there)/guides/how-many-antibiotics-are-there
- [How many antibody-drug conjugates are FDA approved?](https://proteiniq.io/guides/fda-approved-adcs)/guides/fda-approved-adcs
- [How many atoms are in the human body?](https://proteiniq.io/guides/how-many-atoms-in-human-body)/guides/how-many-atoms-in-human-body
- [How many ATP are produced in cellular respiration?](https://proteiniq.io/guides/how-many-atp-are-produced-in-cellular-respiration)/guides/how-many-atp-are-produced-in-cellular-respiration
- [How many ATP are produced in fermentation?](https://proteiniq.io/guides/how-many-atp-are-produced-in-fermentation)/guides/how-many-atp-are-produced-in-fermentation
- [How many ATP are produced in glycolysis?](https://proteiniq.io/guides/how-many-atp-are-produced-in-glycolysis)/guides/how-many-atp-are-produced-in-glycolysis
- [How many ATP are produced in oxidative phosphorylation?](https://proteiniq.io/guides/how-many-atp-are-produced-in-oxidative-phosphorylation)/guides/how-many-atp-are-produced-in-oxidative-phosphorylation
- [How many ATP are produced in the Krebs cycle?](https://proteiniq.io/guides/how-many-atp-are-produced-in-the-krebs-cycle)/guides/how-many-atp-are-produced-in-the-krebs-cycle
- [How many ATP does beta oxidation produce?](https://proteiniq.io/guides/how-many-atp-does-beta-oxidation-produce)/guides/how-many-atp-does-beta-oxidation-produce
- [How many bacteria are in the human body?](https://proteiniq.io/guides/how-many-bacteria-are-in-the-human-body)/guides/how-many-bacteria-are-in-the-human-body
- [How many bispecific antibodies are approved?](https://proteiniq.io/guides/approved-bispecific-antibodies)/guides/approved-bispecific-antibodies
- [How many cell types are in the human body?](https://proteiniq.io/guides/how-many-cell-types-are-in-the-human-body)/guides/how-many-cell-types-are-in-the-human-body
- [How many cells are in the human body?](https://proteiniq.io/guides/how-many-cells-are-in-the-human-body)/guides/how-many-cells-are-in-the-human-body
- [How many chromosomes do different species have?](https://proteiniq.io/guides/chromosome-counts-by-species)/guides/chromosome-counts-by-species
- [How many chromosomes do humans have?](https://proteiniq.io/guides/how-many-chromosomes-do-humans-have)/guides/how-many-chromosomes-do-humans-have
- [How many codons are there?](https://proteiniq.io/guides/how-many-codons-are-there)/guides/how-many-codons-are-there
- [How many covalent drugs are approved?](https://proteiniq.io/guides/approved-covalent-drugs)/guides/approved-covalent-drugs
- [How many CpG sites are in the human genome?](https://proteiniq.io/guides/how-many-cpg-sites-in-human-genome)/guides/how-many-cpg-sites-in-human-genome
- [How many diseases are there? Counts, types, and stages](https://proteiniq.io/guides/how-many-diseases-are-there)/guides/how-many-diseases-are-there
- [How many drug targets are there?](https://proteiniq.io/guides/drug-targets)/guides/drug-targets
- [How many druggable genes are there?](https://proteiniq.io/guides/druggable-genome)/guides/druggable-genome
- [How many enzymes are in the human body?](https://proteiniq.io/guides/how-many-enzymes-are-in-the-human-body)/guides/how-many-enzymes-are-in-the-human-body
- [How many FDA-approved drugs are there?](https://proteiniq.io/guides/how-many-fda-approved-drugs)/guides/how-many-fda-approved-drugs
- [How many genes are in a chromosome?](https://proteiniq.io/guides/how-many-genes-are-in-a-chromosome)/guides/how-many-genes-are-in-a-chromosome
- [How many genes are in mitochondrial DNA?](https://proteiniq.io/guides/how-many-genes-in-mitochondrial-dna)/guides/how-many-genes-in-mitochondrial-dna
- [How many genes do humans have?](https://proteiniq.io/guides/how-many-genes-do-humans-have)/guides/how-many-genes-do-humans-have
- [How many genomes have been sequenced?](https://proteiniq.io/guides/genbank-statistics)/guides/genbank-statistics
- [How many hemoglobin molecules are in a red blood cell?](https://proteiniq.io/guides/how-many-hemoglobin-molecules-in-a-red-blood-cell)/guides/how-many-hemoglobin-molecules-in-a-red-blood-cell
- [How many medicines are there in the world?](https://proteiniq.io/guides/how-many-medicines-are-there-in-the-world)/guides/how-many-medicines-are-there-in-the-world
- [How many mitochondria are in a cell?](https://proteiniq.io/guides/how-many-mitochondria-are-in-a-cell)/guides/how-many-mitochondria-are-in-a-cell
- [How many monoclonal antibodies are FDA approved?](https://proteiniq.io/guides/how-many-monoclonal-antibodies-are-fda-approved)/guides/how-many-monoclonal-antibodies-are-fda-approved
- [How many NADH are produced in glycolysis?](https://proteiniq.io/guides/how-many-nadh-are-produced-in-glycolysis)/guides/how-many-nadh-are-produced-in-glycolysis
- [How many neurons are in the human brain?](https://proteiniq.io/guides/how-many-neurons-are-in-the-human-brain)/guides/how-many-neurons-are-in-the-human-brain
- [How many nucleosomes are in a human cell?](https://proteiniq.io/guides/how-many-nucleosomes-are-in-a-human-cell)/guides/how-many-nucleosomes-are-in-a-human-cell
- [How many oligonucleotide drugs are approved?](https://proteiniq.io/guides/approved-oligonucleotide-drugs)/guides/approved-oligonucleotide-drugs
- [How many peptide bonds are in a peptide?](https://proteiniq.io/guides/how-many-peptide-bonds-in-a-peptide)/guides/how-many-peptide-bonds-in-a-peptide
- [How many peptide drugs are FDA approved?](https://proteiniq.io/guides/fda-approved-peptide-drugs)/guides/fda-approved-peptide-drugs
- [How many platelets are in the human body?](https://proteiniq.io/guides/how-many-platelets-are-in-the-human-body)/guides/how-many-platelets-are-in-the-human-body
- [How many protein interactions are in the human interactome?](https://proteiniq.io/guides/human-interactome-statistics)/guides/human-interactome-statistics
- [How many proteins are there?](https://proteiniq.io/guides/number-of-proteins)/guides/number-of-proteins
- [How many radiopharmaceutical therapies are approved?](https://proteiniq.io/guides/approved-radiopharmaceutical-therapies)/guides/approved-radiopharmaceutical-therapies
- [How many red blood cells are in the human body?](https://proteiniq.io/guides/how-many-red-blood-cells-are-in-the-human-body)/guides/how-many-red-blood-cells-are-in-the-human-body
- [How many ribosomes are in a cell?](https://proteiniq.io/guides/how-many-ribosomes-are-in-a-cell)/guides/how-many-ribosomes-are-in-a-cell
- [How many RNA polymerases do eukaryotes have?](https://proteiniq.io/guides/how-many-rna-polymerases-do-eukaryotes-have)/guides/how-many-rna-polymerases-do-eukaryotes-have
- [How many SNPs are in the human genome?](https://proteiniq.io/guides/how-many-snps-are-in-the-human-genome)/guides/how-many-snps-are-in-the-human-genome
- [How many transcripts are in the human transcriptome?](https://proteiniq.io/guides/human-transcriptome-size)/guides/human-transcriptome-size
- [How many types of antibodies are there?](https://proteiniq.io/guides/how-many-types-of-antibodies-are-there)/guides/how-many-types-of-antibodies-are-there
- [How many types of proteins are in the human body?](https://proteiniq.io/guides/types-of-proteins-in-human-body)/guides/types-of-proteins-in-human-body
- [How many types of RNA are there?](https://proteiniq.io/guides/how-many-types-of-rna-are-there)/guides/how-many-types-of-rna-are-there
- [How many viruses infect humans?](https://proteiniq.io/guides/how-many-viruses-infect-humans)/guides/how-many-viruses-infect-humans
- [How many white blood cells are in the human body?](https://proteiniq.io/guides/how-many-white-blood-cells-are-in-the-human-body)/guides/how-many-white-blood-cells-are-in-the-human-body
- [How much DNA do cousins share?](https://proteiniq.io/guides/how-much-dna-do-cousins-share)/guides/how-much-dna-do-cousins-share
- [How much DNA do humans share with bananas?](https://proteiniq.io/guides/human-banana-dna-similarity)/guides/human-banana-dna-similarity
- [How much DNA do humans share with chimpanzees?](https://proteiniq.io/guides/human-chimp-dna-similarity)/guides/human-chimp-dna-similarity
- [How much DNA do humans share with other animals?](https://proteiniq.io/guides/human-animal-dna-similarity)/guides/human-animal-dna-similarity
- [How much DNA do humans share with pigs?](https://proteiniq.io/guides/human-pig-dna-similarity)/guides/human-pig-dna-similarity
- [How much DNA do siblings share?](https://proteiniq.io/guides/how-much-dna-do-siblings-share)/guides/how-much-dna-do-siblings-share
- [How much DNA is needed for sequencing?](https://proteiniq.io/guides/how-much-dna-is-needed-for-sequencing)/guides/how-much-dna-is-needed-for-sequencing
- [How much do monoclonal antibodies cost?](https://proteiniq.io/guides/monoclonal-antibody-cost)/guides/monoclonal-antibody-cost
- [How much does drug development cost?](https://proteiniq.io/guides/drug-development-cost)/guides/drug-development-cost
- [How much does it cost to sequence a genome?](https://proteiniq.io/guides/genome-sequencing-cost)/guides/genome-sequencing-cost
- [How much does peptide synthesis cost?](https://proteiniq.io/guides/peptide-synthesis-cost)/guides/peptide-synthesis-cost
- [How much is the pharmaceutical industry worth?](https://proteiniq.io/guides/how-much-is-the-pharmaceutical-industry-worth)/guides/how-much-is-the-pharmaceutical-industry-worth
- [How much of the human genome is junk DNA?](https://proteiniq.io/guides/human-genome-junk-dna)/guides/human-genome-junk-dna
- [How to draw chemical structures online for free](https://proteiniq.io/guides/draw-chemical-structures-online)/guides/draw-chemical-structures-online
- [How to draw stereochemistry: wedges, dashes and R/S labels](https://proteiniq.io/guides/stereochemistry-wedges-dashes)/guides/stereochemistry-wedges-dashes
- [How to make a FASTA file](https://proteiniq.io/guides/how-to-make-a-fasta-file)/guides/how-to-make-a-fasta-file
- [How to make publication-quality chemical structure images](https://proteiniq.io/guides/publication-quality-chemical-structures)/guides/publication-quality-chemical-structures
- [How to open a CDX or CDXML file without ChemDraw](https://proteiniq.io/guides/open-cdx-cdxml-without-chemdraw)/guides/open-cdx-cdxml-without-chemdraw
- [How to open a PDB file](https://proteiniq.io/guides/open-pdb-file)/guides/open-pdb-file
- [How to predict pKa online for free](https://proteiniq.io/guides/predict-pka-online)/guides/predict-pka-online
- [How to read a Ramachandran plot](https://proteiniq.io/guides/ramachandran-plot)/guides/ramachandran-plot
- [How to tell if a predicted protein structure is reliable](https://proteiniq.io/guides/structure-prediction-confidence)/guides/structure-prediction-confidence
- [Human vs humanized vs chimeric antibodies: the origin of every FDA-approved antibody](https://proteiniq.io/guides/humanized-vs-fully-human-antibodies)/guides/humanized-vs-fully-human-antibodies

## I

- [IC50 vs Ki vs Kd: what each measures and how to convert them](https://proteiniq.io/guides/ic50-vs-ki)/guides/ic50-vs-ki
- [InChI, InChIKey, SMILES and CAS numbers: what each identifier is for](https://proteiniq.io/guides/inchi-inchikey-smiles-cas)/guides/inchi-inchikey-smiles-cas
- [Insulin prices and price history in the United States](https://proteiniq.io/guides/insulin-price-history)/guides/insulin-price-history
- [Introns vs exons: what is the difference?](https://proteiniq.io/guides/introns-vs-exons)/guides/introns-vs-exons
- [ipSAE explained](https://proteiniq.io/guides/ipsae)/guides/ipsae
- [ipTM vs pTM: judging predicted complexes](https://proteiniq.io/guides/iptm-vs-ptm)/guides/iptm-vs-ptm
- [Isoelectric point of a protein: what pI means and how it is calculated](https://proteiniq.io/guides/protein-isoelectric-point)/guides/protein-isoelectric-point

## K

- [Kyte-Doolittle hydropathy scale and how to read a hydropathy plot](https://proteiniq.io/guides/kyte-doolittle-hydropathy)/guides/kyte-doolittle-hydropathy

## L

- [Lipinski's rule of five](https://proteiniq.io/guides/lipinski-rule-of-five)/guides/lipinski-rule-of-five

## M

- [mBER and ColabDesign metrics explained](https://proteiniq.io/guides/mber-metrics)/guides/mber-metrics
- [MM/PBSA vs MM/GBSA: how end-point binding free energies work](https://proteiniq.io/guides/mm-pbsa-vs-mm-gbsa)/guides/mm-pbsa-vs-mm-gbsa
- [Molecular weight vs exact mass, and how to calculate HRMS ions](https://proteiniq.io/guides/molecular-weight-exact-mass)/guides/molecular-weight-exact-mass

## O

- [Oligo analyzer comparison](https://proteiniq.io/guides/oligo-analyzer-comparison)/guides/oligo-analyzer-comparison
- [Ozempic: What it is & latest statistics](https://proteiniq.io/guides/ozempic-statistics)/guides/ozempic-statistics

## P

- [PAINS filters and pan-assay interference compounds](https://proteiniq.io/guides/pains-filters)/guides/pains-filters
- [Phylogenetic tree: what it shows and how to read one](https://proteiniq.io/guides/phylogenetic-tree)/guides/phylogenetic-tree
- [Post-translational modifications: types, examples and what they do](https://proteiniq.io/guides/post-translational-modifications)/guides/post-translational-modifications
- [Primer dimers: how they form, how to predict them and how to stop them](https://proteiniq.io/guides/primer-dimers)/guides/primer-dimers
- [PROTACs and molecular glue degraders in clinical trials](https://proteiniq.io/guides/protein-degraders-clinical-trials)/guides/protein-degraders-clinical-trials
- [Protein aggregation: causes, prediction and prevention](https://proteiniq.io/guides/protein-aggregation)/guides/protein-aggregation
- [Protein Data Bank statistics 2026: size and coverage](https://proteiniq.io/guides/rcsb-statistics)/guides/rcsb-statistics
- [Protein extinction coefficient and A280 concentration](https://proteiniq.io/guides/protein-extinction-coefficient)/guides/protein-extinction-coefficient
- [Proteome sizes by species: protein counts compared](https://proteiniq.io/guides/proteome-sizes-by-species)/guides/proteome-sizes-by-species

## R

- [RNA secondary structure: dot-bracket notation and MFE explained](https://proteiniq.io/guides/rna-secondary-structure)/guides/rna-secondary-structure

## S

- [SDF file format: how SDF and MOL files work](https://proteiniq.io/guides/sdf-file)/guides/sdf-file
- [Semaglutide vs tirzepatide](https://proteiniq.io/guides/semaglutide-vs-tirzepatide)/guides/semaglutide-vs-tirzepatide
- [SignalP 6.0: official server, tutorial, and result interpretation](https://proteiniq.io/guides/what-is-signalp-6)/guides/what-is-signalp-6
- [SMILES notation: how to read and write SMILES strings](https://proteiniq.io/guides/smiles-notation)/guides/smiles-notation

## T

- [The best free ChemDraw alternatives in 2026](https://proteiniq.io/guides/chemdraw-alternatives)/guides/chemdraw-alternatives
- [The best free molecular docking software in 2026](https://proteiniq.io/guides/molecular-docking-software)/guides/molecular-docking-software
- [The best free molecular dynamics software in 2026](https://proteiniq.io/guides/molecular-dynamics-software)/guides/molecular-dynamics-software
- [The best phylogenetic tree software in 2026](https://proteiniq.io/guides/phylogenetic-tree-software)/guides/phylogenetic-tree-software
- [The best protein structure prediction software in 2026](https://proteiniq.io/guides/protein-structure-prediction-software)/guides/protein-structure-prediction-software
- [TM-score vs RMSD](https://proteiniq.io/guides/tm-score-vs-rmsd)/guides/tm-score-vs-rmsd

## W

- [What are antibodies?](https://proteiniq.io/guides/what-are-antibodies)/guides/what-are-antibodies
- [What are monoclonal antibodies?](https://proteiniq.io/guides/what-are-monoclonal-antibodies)/guides/what-are-monoclonal-antibodies
- [What are the largest and smallest cells in the human body?](https://proteiniq.io/guides/largest-and-smallest-cells)/guides/largest-and-smallest-cells
- [What are the largest and smallest human genes?](https://proteiniq.io/guides/largest-and-smallest-human-genes)/guides/largest-and-smallest-human-genes
- [What are the most acidic and basic amino acids?](https://proteiniq.io/guides/most-acidic-and-basic-amino-acids)/guides/most-acidic-and-basic-amino-acids
- [What clashscore means and what counts as good](https://proteiniq.io/guides/clashscore)/guides/clashscore
- [What is a CIF file? Small-molecule CIF and mmCIF explained](https://proteiniq.io/guides/cif-file)/guides/cif-file
- [What is a protein language model, and what is it used for](https://proteiniq.io/guides/protein-language-models)/guides/protein-language-models
- [What is a Vina score, and what counts as good](https://proteiniq.io/guides/vina-score)/guides/vina-score
- [What is antibody engineering?](https://proteiniq.io/guides/what-is-antibody-engineering)/guides/what-is-antibody-engineering
- [What is Chai-2? De novo antibody design explained](https://proteiniq.io/guides/what-is-chai-2)/guides/what-is-chai-2
- [What is PAE, and how to read a PAE plot](https://proteiniq.io/guides/pae)/guides/pae
- [What is pentobarbital?](https://proteiniq.io/guides/pentobarbital)/guides/pentobarbital
- [What is pLDDT, and what counts as a good score](https://proteiniq.io/guides/plddt)/guides/plddt
- [What is protein denaturation?](https://proteiniq.io/guides/protein-denaturation)/guides/protein-denaturation
- [What is RMSD, and what counts as a good value](https://proteiniq.io/guides/rmsd)/guides/rmsd
- [What is semaglutide?](https://proteiniq.io/guides/semaglutide)/guides/semaglutide
- [What is the average size of a protein?](https://proteiniq.io/guides/average-protein-size)/guides/average-protein-size
- [What is the fastest enzyme?](https://proteiniq.io/guides/fastest-enzyme)/guides/fastest-enzyme
- [What is the largest protein?](https://proteiniq.io/guides/largest-protein)/guides/largest-protein
- [What is the molecular weight of an antibody?](https://proteiniq.io/guides/antibody-molecular-weight)/guides/antibody-molecular-weight
- [What is the most abundant protein in the human body?](https://proteiniq.io/guides/most-abundant-protein-in-human-body)/guides/most-abundant-protein-in-human-body
- [What is the most abundant protein on Earth?](https://proteiniq.io/guides/most-abundant-protein-on-earth)/guides/most-abundant-protein-on-earth
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