{
  "checked": "2026-10-29",
  "source_csv": "protein-degraders-clinical-trials.csv",
  "assets_counted": 102,
  "assets_active": 73,
  "by_modality": {
    "PROTAC": 54,
    "Molecular glue": 28,
    "Other": 7,
    "Undisclosed": 13
  },
  "active_by_modality": {
    "PROTAC": 37,
    "Molecular glue": 20,
    "Other": 4,
    "Undisclosed": 12
  },
  "by_status": {
    "Active": 73,
    "Discontinued": 22,
    "Unclear": 7
  },
  "status_by_modality": {
    "PROTAC": {
      "Active": 37,
      "Discontinued": 15,
      "Unclear": 2
    },
    "Molecular glue": {
      "Active": 20,
      "Discontinued": 4,
      "Unclear": 4
    },
    "Other": {
      "Active": 4,
      "Discontinued": 2,
      "Unclear": 1
    },
    "Undisclosed": {
      "Active": 12,
      "Discontinued": 1,
      "Unclear": 0
    }
  },
  "by_highest_phase": {
    "Phase 1": 63,
    "Phase 1/2": 20,
    "Phase 2": 10,
    "Phase 3": 7,
    "Approved": 2
  },
  "highest_phase_by_modality": {
    "Phase 1": {
      "PROTAC": 32,
      "Molecular glue": 17,
      "Other": 5,
      "Undisclosed": 9
    },
    "Phase 1/2": {
      "PROTAC": 12,
      "Molecular glue": 4,
      "Other": 1,
      "Undisclosed": 3
    },
    "Phase 2": {
      "PROTAC": 5,
      "Molecular glue": 4,
      "Other": 0,
      "Undisclosed": 1
    },
    "Phase 3": {
      "PROTAC": 4,
      "Molecular glue": 2,
      "Other": 1,
      "Undisclosed": 0
    },
    "Approved": {
      "PROTAC": 1,
      "Molecular glue": 1,
      "Other": 0,
      "Undisclosed": 0
    }
  },
  "active_highest_phase_by_modality": {
    "Phase 1": {
      "PROTAC": 18,
      "Molecular glue": 12,
      "Other": 3,
      "Undisclosed": 9
    },
    "Phase 1/2": {
      "PROTAC": 11,
      "Molecular glue": 2,
      "Other": 0,
      "Undisclosed": 3
    },
    "Phase 2": {
      "PROTAC": 3,
      "Molecular glue": 3,
      "Other": 0,
      "Undisclosed": 0
    },
    "Phase 3": {
      "PROTAC": 4,
      "Molecular glue": 2,
      "Other": 1,
      "Undisclosed": 0
    },
    "Approved": {
      "PROTAC": 1,
      "Molecular glue": 1,
      "Other": 0,
      "Undisclosed": 0
    }
  },
  "by_e3_ligase": {
    "CRBN": 47,
    "Undisclosed": 45,
    "Not applicable": 4,
    "VHL": 3,
    "Other": 2,
    "DCAF15": 1
  },
  "e3_ligase_by_modality": {
    "PROTAC": {
      "Undisclosed": 29,
      "CRBN": 22,
      "VHL": 3
    },
    "Molecular glue": {
      "CRBN": 22,
      "Undisclosed": 3,
      "Other": 2,
      "DCAF15": 1
    },
    "Other": {
      "Not applicable": 4,
      "CRBN": 3
    },
    "Undisclosed": {
      "Undisclosed": 13
    }
  },
  "by_primary_target": {
    "Androgen receptor": 12,
    "BTK": 10,
    "IKZF1/3": 9,
    "GSPT1": 7,
    "IRAK4": 6,
    "KRAS": 6,
    "Estrogen receptor alpha": 5,
    "EGFR": 4,
    "BCL6": 3,
    "CDK2": 3,
    "SMARCA2": 3,
    "BRD4": 2,
    "BRD9": 2,
    "CK1 alpha": 2,
    "HPK1": 2,
    "IKZF2": 2,
    "STAT6": 2,
    "VAV1": 2,
    "ALK": 1,
    "ARNT": 1,
    "BCL-XL": 1,
    "BRAF": 1,
    "CDK4": 1,
    "Galactose-deficient IgA1": 1,
    "HuR": 1,
    "IRF5": 1,
    "IgG": 1,
    "KAT2A": 1,
    "LRRK2": 1,
    "MDM2": 1,
    "NEK7": 1,
    "Pan-TRK": 1,
    "RBM39": 1,
    "STAT3": 1,
    "Undisclosed": 1,
    "WEE1": 1,
    "ZBTB7A": 1,
    "c-Myc": 1
  },
  "active_by_primary_target": {
    "Androgen receptor": 10,
    "BTK": 8,
    "IKZF1/3": 6,
    "KRAS": 5,
    "BCL6": 3,
    "CDK2": 3,
    "EGFR": 3,
    "Estrogen receptor alpha": 3,
    "GSPT1": 3,
    "IRAK4": 3,
    "HPK1": 2,
    "STAT6": 2,
    "VAV1": 2,
    "ALK": 1,
    "ARNT": 1,
    "BCL-XL": 1,
    "BRD4": 1,
    "CDK4": 1,
    "CK1 alpha": 1,
    "Galactose-deficient IgA1": 1,
    "HuR": 1,
    "IRF5": 1,
    "IgG": 1,
    "KAT2A": 1,
    "LRRK2": 1,
    "NEK7": 1,
    "Pan-TRK": 1,
    "RBM39": 1,
    "SMARCA2": 1,
    "Undisclosed": 1,
    "WEE1": 1,
    "ZBTB7A": 1,
    "c-Myc": 1
  },
  "by_therapeutic_area": {
    "Oncology": 83,
    "Immunology and inflammation": 14,
    "Other": 3,
    "Neurology": 2
  },
  "first_in_human_by_year": {
    "2011": {
      "PROTAC": 0,
      "Molecular glue": 1,
      "Other": 0,
      "Undisclosed": 0
    },
    "2012": {
      "PROTAC": 0,
      "Molecular glue": 1,
      "Other": 0,
      "Undisclosed": 0
    },
    "2013": {
      "PROTAC": 0,
      "Molecular glue": 0,
      "Other": 0,
      "Undisclosed": 0
    },
    "2014": {
      "PROTAC": 0,
      "Molecular glue": 0,
      "Other": 0,
      "Undisclosed": 0
    },
    "2015": {
      "PROTAC": 0,
      "Molecular glue": 0,
      "Other": 0,
      "Undisclosed": 0
    },
    "2016": {
      "PROTAC": 0,
      "Molecular glue": 1,
      "Other": 0,
      "Undisclosed": 0
    },
    "2017": {
      "PROTAC": 0,
      "Molecular glue": 0,
      "Other": 0,
      "Undisclosed": 0
    },
    "2018": {
      "PROTAC": 0,
      "Molecular glue": 1,
      "Other": 0,
      "Undisclosed": 0
    },
    "2019": {
      "PROTAC": 2,
      "Molecular glue": 3,
      "Other": 0,
      "Undisclosed": 0
    },
    "2020": {
      "PROTAC": 1,
      "Molecular glue": 0,
      "Other": 0,
      "Undisclosed": 0
    },
    "2021": {
      "PROTAC": 10,
      "Molecular glue": 3,
      "Other": 0,
      "Undisclosed": 0
    },
    "2022": {
      "PROTAC": 8,
      "Molecular glue": 2,
      "Other": 2,
      "Undisclosed": 0
    },
    "2023": {
      "PROTAC": 10,
      "Molecular glue": 2,
      "Other": 0,
      "Undisclosed": 1
    },
    "2024": {
      "PROTAC": 10,
      "Molecular glue": 6,
      "Other": 1,
      "Undisclosed": 3
    },
    "2025": {
      "PROTAC": 7,
      "Molecular glue": 5,
      "Other": 2,
      "Undisclosed": 7
    },
    "2026": {
      "PROTAC": 6,
      "Molecular glue": 3,
      "Other": 2,
      "Undisclosed": 2
    }
  },
  "cumulative_by_end_of_year": {
    "2011": 1,
    "2012": 2,
    "2013": 2,
    "2014": 2,
    "2015": 2,
    "2016": 3,
    "2017": 3,
    "2018": 4,
    "2019": 9,
    "2020": 10,
    "2021": 23,
    "2022": 35,
    "2023": 48,
    "2024": 68,
    "2025": 89,
    "2026": 102
  },
  "not_counted": {
    "AXT-1003": "Mechanism disputed",
    "BHV-1310": "No confirmed human dosing",
    "CT-01": "No trial with an actual start by 2026-10-29",
    "E7820": "Developed before its glue mechanism was known; reference row",
    "ETX-636": "Inhibitor that also triggers degradation, excluded like SERDs",
    "HJ-004-02": "No trial with an actual start by 2026-10-29",
    "HLD-0915": "Not a degrader (RIPTAC)",
    "HP568": "No trial with an actual start by 2026-10-29",
    "Indisulam": "Developed before its glue mechanism was known; reference row",
    "Lenalidomide": "Developed before its glue mechanism was known; reference row",
    "MDSY-1240": "No trial with an actual start by 2026-10-29",
    "Pomalidomide": "Developed before its glue mechanism was known; reference row",
    "PRT13722": "First trial not yet recruiting on 2026-10-29",
    "SP-3164": "No trial with an actual start by 2026-10-29",
    "Thalidomide": "Developed before its glue mechanism was known; reference row",
    "TQB3201": "No trial with an actual start by 2026-10-29",
    "TQB3205": "Mechanism disputed",
    "ZE66-0205": "No trial with an actual start by 2026-10-29"
  }
}