{
  "license": "CC BY-SA 3.0, derived from ChEMBL; credit ChEMBL (Zdrazil et al., Nucleic Acids Research, 2024) and ProteinIQ",
  "chembl_release": "ChEMBL_37",
  "chembl_release_date": "2026-05-01",
  "api": "https://www.ebi.ac.uk/chembl/api/data",
  "retrieved_at": "2026-10-29T15:48:06+00:00",
  "filters": {
    "approved": "molecule max_phase = 4, parent molecules only (molecule_hierarchy), therapeutic_flag = true",
    "mechanism": "drug_mechanism rows for those parents with disease_efficacy = 1 and a non-null target"
  },
  "drugs": {
    "max_phase_4_molecules_incl_salts": 4225,
    "max_phase_4_parents": 2996,
    "excluded_non_therapeutic_parents": 485,
    "approved_therapeutic_drugs": 2511,
    "withdrawn_flag_among_them": 150,
    "by_molecule_type": {
      "Small molecule": 1897,
      "Protein": 211,
      "Oligosaccharide": 11,
      "Unknown": 84,
      "Enzyme": 49,
      "Antibody": 142,
      "Oligonucleotide": 20,
      "Antibody drug conjugate": 13,
      "Cell": 9,
      "Gene": 21,
      "Vaccine component": 54
    },
    "by_modality": {
      "Small molecule": 1897,
      "Biologic": 499,
      "Other": 115
    },
    "with_mechanism_record": 2421,
    "with_known_target": 2205,
    "with_known_target_by_modality": {
      "Small molecule": 1664,
      "Biologic": 463,
      "Other": 78
    },
    "with_human_target": 1791,
    "with_pathogen_targets_only": 390,
    "drug_target_links": 2846,
    "targets_per_drug_median": 1
  },
  "targets": {
    "distinct_targets": 809,
    "by_organism_group": {
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      "Pathogen or parasite": 179,
      "No organism": 19
    },
    "by_target_kind": {
      "Single protein": 531,
      "Protein complex": 92,
      "Protein-protein interaction": 2,
      "Protein family or group": 80,
      "Non-protein": 104
    },
    "human_by_target_kind": {
      "Single protein": 428,
      "Protein complex": 58,
      "Protein-protein interaction": 2,
      "Protein family or group": 73,
      "Non-protein": 50
    },
    "pathogen_by_target_kind": {
      "Single protein": 103,
      "Protein complex": 34,
      "Non-protein": 35,
      "Protein family or group": 7
    },
    "human_protein_targets": 561,
    "human_proteins_behind_targets": 984,
    "human_proteins_as_single_protein_targets": 428,
    "human_by_class": {
      "GPCRs": 110,
      "Ion channels": 50,
      "Protein kinases": 82,
      "Nuclear receptors": 18,
      "Proteases": 29,
      "Other enzymes": 116,
      "Transporters": 21,
      "Epigenetic regulators": 10,
      "Other membrane receptors": 32,
      "Other transcription factors": 3,
      "Secreted proteins": 33,
      "Surface antigens": 9,
      "Other or unclassified proteins": 38,
      "Mixed classes": 10,
      "Non-protein targets": 50
    },
    "human_proteins_by_class": {
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      "Ion channels": 133,
      "Protein kinases": 94,
      "Nuclear receptors": 19,
      "Proteases": 28,
      "Other enzymes": 216,
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      "Epigenetic regulators": 17,
      "Other membrane receptors": 40,
      "Other transcription factors": 3,
      "Secreted proteins": 39,
      "Surface antigens": 9,
      "Other or unclassified proteins": 170,
      "Mixed classes": 116,
      "Non-protein targets": 0
    },
    "pathogen_by_organism_type": {
      "Virus": 45,
      "Parasite": 26,
      "Fungus": 20,
      "Bacterium": 88
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    "targets_with_one_approved_drug": 420,
    "human_targets_with_one_approved_drug": 285,
    "human_targets_dated": 591,
    "new_human_targets_by_decade": {
      "before 1950": 29,
      "1950s": 58,
      "1960s": 30,
      "1970s": 37,
      "1980s": 49,
      "1990s": 66,
      "2000s": 94,
      "2010s": 137,
      "2020s": 91
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    "new_human_targets_since_2010_by_class": {
      "Protein kinases": 47,
      "Other enzymes": 32,
      "GPCRs": 27,
      "Other or unclassified proteins": 27,
      "Non-protein targets": 24,
      "Secreted proteins": 20,
      "Other membrane receptors": 11,
      "Proteases": 11,
      "Ion channels": 8,
      "Surface antigens": 4,
      "Transporters": 4,
      "Mixed classes": 4,
      "Nuclear receptors": 3,
      "Other transcription factors": 3,
      "Epigenetic regulators": 3
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  },
  "gpcr_share_by_denominator": {
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      "gpcr_drugs": 402,
      "denominator": 1664,
      "pct": 24.2
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    "all_drugs_with_known_target": {
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      "denominator": 2205,
      "pct": 22.0
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    "small_molecules_all": {
      "gpcr_drugs": 402,
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      "pct": 21.2
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    "all_therapeutic_approved": {
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      "pct": 19.3
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    "all_max_phase_4_parents_incl_non_therapeutic": {
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      "pct": 16.2
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    "first_approved_2015_or_later_with_known_target": {
      "gpcr_drugs": 61,
      "denominator": 464,
      "pct": 13.1
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    "human_targets": {
      "gpcr_targets": 110,
      "denominator": 611,
      "pct": 18.0
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    "antibodies_with_known_target": {
      "gpcr_drugs": 3,
      "denominator": 152,
      "pct": 2.0
    },
    "proteins_and_peptides_with_known_target": {
      "gpcr_drugs": 71,
      "denominator": 206,
      "pct": 34.5
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    "by_first_approval_decade": {
      "before 1950": {
        "approved": 49,
        "gpcr_drugs": 14,
        "denominator": 44,
        "pct": 31.8
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      "1950s": {
        "approved": 149,
        "gpcr_drugs": 41,
        "denominator": 143,
        "pct": 28.7
      },
      "1960s": {
        "approved": 148,
        "gpcr_drugs": 28,
        "denominator": 142,
        "pct": 19.7
      },
      "1970s": {
        "approved": 185,
        "gpcr_drugs": 51,
        "denominator": 175,
        "pct": 29.1
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      "1980s": {
        "approved": 350,
        "gpcr_drugs": 93,
        "denominator": 321,
        "pct": 29.0
      },
      "1990s": {
        "approved": 372,
        "gpcr_drugs": 67,
        "denominator": 348,
        "pct": 19.3
      },
      "2000s": {
        "approved": 345,
        "gpcr_drugs": 70,
        "denominator": 309,
        "pct": 22.7
      },
      "2010s": {
        "approved": 422,
        "gpcr_drugs": 63,
        "denominator": 377,
        "pct": 16.7
      },
      "2020s": {
        "approved": 276,
        "gpcr_drugs": 29,
        "denominator": 247,
        "pct": 11.7
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    },
    "us_prescriptions": {
      "source": "https://clincalc.com/DrugStats/Top300Drugs.aspx",
      "prescription_year": 2024,
      "products": 300,
      "products_with_known_target": 280,
      "gpcr_products": 89,
      "pct_products": 29.7,
      "prescriptions": 2662874247,
      "prescriptions_with_known_target": 2594687239,
      "gpcr_prescriptions": 742847137,
      "pct_prescriptions": 27.9,
      "pct_prescriptions_with_known_target": 28.6
    }
  }
}