{
  "last_checked": "2026-10-29",
  "license": "CC BY 4.0. Credit: ProteinIQ, https://proteiniq.io/guides/approved-radiopharmaceutical-therapies",
  "sources": {
    "fda": "Drugs@FDA data files (Last-Modified October 29, 2026); Purple Book October 2026 download",
    "ema": "EMA medicines report generated October 29, 2026"
  },
  "fda": {
    "active_ingredients_ever_approved": 11,
    "products_listed": 13,
    "active_ingredients_approved_now": 6,
    "active_ingredients_approved_now_list": [
      "ibritumomab tiuxetan (Y-90)",
      "lutetium Lu-177 dotatate",
      "lutetium Lu-177 vipivotide tetraxetan",
      "radium Ra-223 dichloride",
      "sodium iodide I-131",
      "strontium chloride Sr-89"
    ],
    "products_approved_now": [
      "Sodium iodide I-131 (Iodotope, Hicon and generics)",
      "Metastron (strontium chloride Sr-89)",
      "Zevalin (yttrium Y-90 ibritumomab tiuxetan)",
      "Xofigo (radium Ra-223 dichloride)",
      "Lutathera (lutetium Lu-177 dotatate)",
      "Pluvicto (lutetium Lu-177 vipivotide tetraxetan)",
      "Bexlutry (lutetium Lu-177 dotatate)",
      "Bravnetsa (lutetium Lu-177 dotatate)"
    ],
    "no_longer_marketed": [
      "Phosphotope (sodium phosphate P-32)",
      "Phosphocol P32 (chromic phosphate P-32)",
      "Quadramet (samarium Sm-153 lexidronam)",
      "Bexxar (tositumomab and iodine I-131 tositumomab)",
      "Azedra (iobenguane I-131)"
    ],
    "by_class_ever": {
      "Radioactive ion or colloid": 3,
      "Bone-seeking radionuclide": 3,
      "Radioimmunotherapy": 2,
      "Radioligand therapy": 3
    },
    "by_isotope_ever": {
      "I-131": 3,
      "P-32": 2,
      "Sr-89": 1,
      "Sm-153": 1,
      "Y-90": 1,
      "Ra-223": 1,
      "Lu-177": 2
    },
    "radioligand_products_approved_now": [
      "Lutathera (lutetium Lu-177 dotatate)",
      "Pluvicto (lutetium Lu-177 vipivotide tetraxetan)",
      "Bexlutry (lutetium Lu-177 dotatate)",
      "Bravnetsa (lutetium Lu-177 dotatate)"
    ]
  },
  "ema": {
    "therapies_authorised_now": [
      "Quadramet (samarium Sm-153 lexidronam)",
      "Xofigo (radium Ra-223 dichloride)",
      "Lutathera (lutetium Lu-177 dotatate)",
      "Pluvicto (lutetium Lu-177 vipivotide tetraxetan)"
    ],
    "precursors_not_counted": [
      "EndolucinBeta (Authorised)",
      "Lumark (Withdrawn 2026-01-16)",
      "Lutetium (177Lu) chloride Billev (Authorised)",
      "Theralugand (Authorised)",
      "Ilumira (Authorised)",
      "Yttriga (Authorised)"
    ]
  }
}